Head to Head

AGIO vs ASTH: which is the better buy in 2026?

Agios Pharmaceuticals, Inc.

NASDAQ:AGIO

90/100 Compass
True NorthAccumulate$2.4B

A rare disease franchise turning into a multi-indication PK activator platform, with sickle cell as the swing factor.

Full AGIO analysis

Astrana Health, Inc.

NASDAQ:ASTH

90/100 Compass
True NorthAccumulate$2.3B

A capitated-care roll-up trading like a hospital chain, just as risk-bearing primary care eats traditional fee-for-service from the inside.

Full ASTH analysis

Factor by factor

FactorAGIOASTH
Revenue Growth9898
Profitability1832
Valuation7553
Momentum7180
Theme Purity5858
Moat5050
Catalysts6363
Market Position4848

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Frequently asked questions

Is AGIO or ASTH the better buy in 2026?

AGIO and ASTH are neck and neck at 90/100 on the Compass right now. The better fit depends on which factors matter most to you.

How does Alexandria compare AGIO and ASTH?

Each company is scored 1-100 on eight factors: revenue growth, profitability, valuation, momentum, theme purity, moat, catalysts, and market position. The Compass Score is the composite, and the comparison below shows where each name wins factor by factor.

Compass Scores are proprietary editorial research from publicly available data, not investment advice or a recommendation regarding any security. Rankings update weekly.